This study was to estimate the total amount of domestic and imported organic solvents production. Potential hazard was evaluated through the amount and physical properties. According to his primary risk assessment, toluene. MEK and
perchloroethylene
were chosen to analyze the analyze the solvents in air and their metabolites in blood and urine for using in biological monitoring in the future.
@ES The results were as follows.
@EN 1. The amount organic solvent consumption was about 3 million tons in 1989. Of all organic solvents, 70% were aromatic hydrocabons, 12% alcohols, 5% ketones, 3% aliphatic hydrocabons respectively. Xylene in aromatic hydrocabons, cyclohexane
in
aliphatic hydrocarbons, methanol in alcohols, acetone in ketones, and trichoroethylene in chlorinated hydrocarbons have been more frequently consumed.
2. Benzene was the most hazardous solvent followed by carbon tetrachloride, methanol, toluene, xylene and its derivatives, dichloromethane, chloroform, ethylene tetrachloride, cyclohexane and MEK. Respectively. Of the chlorinated hydrocabons,
all
except methylchloroform were relatively, hazardous in this assessment.
3. The MEK in urine was a good indicator to pridice MEK exposure. The MEK in blood had high correlation with the MEK in urine. Both the blood and urine MEK were more specific when subjects were exposed to higher level. The urine and blood MEK
corresponded to exposure of 200ppm MEK were 1.37mg/1 and 2.83mg/1.
4. The perchloroethylene in blood and trichloroactic acid in urine were good indicators to predict perchoroethylene exposure. Both the pechloroethylene in blood and trichloroacetic acid in urine were more specific specific when subjects were
exposed to
higher level. The perchloroethylene in blood and trichloroacetic acid in urine corresponded to exposure of 50ppm perchloroethylene were 1.43mg/1 and 2.56mg/1
5. The hippuric acid in urine and toluene in blood were good indicators to predict toluene exposure. The corrected hippuric acid with creatinine was more useful to exposure to toluene. The toluene in blood was more useful than the hippuric acid
in
urine, even if subjects were exposed to lower level. The hippuric acid in urine and toluene in blood correspond to exposure of 100ppm toluene were 1.71g/g creatinine and 2.06mg/1
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